PBT: CMR: Persistenta Cancerogena Bioackumulerande Mutagena Toxiska Reproduktionsstörande Naturfrämmande värstingar Många klor- och bromföreningar förknippas med särskilt allvarliga miljö- och hälsoeffekter. Dessa inkluderar effektkategorier som enligt rutan ovan kort brukar betecknas PBT och CMR

Feb 28, 2017 JANUS expands the prioritization for PBT developed previously by the PBT ( persistent, bioaccumulative and toxic), CMR (carcinogenic,

2 MANUFACTURE AND USES Two companies have provided information on the substance under Regulation 93/793/EEC. ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO. 40 01.02.2007 4 4.1.3 Other information 1 BIOWIN v4.02 gives an overall prediction that the substance is not readily biodegradable. However, some degradation is expected to occur according to the models. 4.1.4 Summary and discussion of persistence Proposal for identification of a substance as a CMR, PBT, vPvB or a substance of an equivalent level of concern Substance Name: Coal tar pitch, high temperature EC Number: 266-028-2 CAS number: 65996-93-2 Submitted by : European Chemicals Agency (ECHA) Version : August 2009 Predicting PBT and CMR properties of substances of very high concern (SVHCs) using QSAR models, and application for K-REACH. Toxicol Rep. 2020 Aug 15;7:995-1000. doi: 10.1016/j.toxrep.2020.08.014.

Screened Chemistry Not Acceptable (High Priority): CMR, PBT (monomer and polymer) doesn’t Meet Safer Choice Polymer Criteria due to CMR/PBT OR contains residual monomer with CMR/PBT hazards at ≥1000 ppm (0.1%). PBT Information System provides with information on Existing Substances which have been subject to evaluation of their PBT properties under the Interim Strategy for REACH and the ESR program. 127 Existing Chemicals and 101 New Substances respectively were evaluated for their PBT/vPvB properties. To identify CMRs, the EU Regulation on Classification, Labelling and Packaging (CLP, EC 1272/2008) has been used as a source. The CLP regulation contains a register of all officially classified substances including CMR substances in category 1A or 1B.

ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO. 4 JUSTIFICATION 1 IDENTIFICATION OF THE SUBSTANCE AND PHYSICAL AND CHEMICAL PROPERTIES Name: 1,2,4-trichlorobenzene EC Number: 204-428-0 CAS Number: 120-82-1 IUPAC Name: 1,2,4-trichlorobenzene Molecular Formula: C6 H3 Cl3 Structural Formula: Cl Cl Cl Molecular Weight: 181.46

To identify CMRs, the EU Regulation on Classification, Labelling and Packaging (CLP, EC 1272/2008) has been used as a source. The CLP regulation contains a register of all officially classified substances including CMR substances in category 1A or 1B. ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO.97 A study investigated the degradation of several rubber chemicals in aerated water (Monsanto 1979a).

These are called CMR substances (Carcinogenic, Mutagenic or Toxic to reproduction). Then there are harmful substances that do not easily break down and accumulate in the food chain. These are known as PBT substances (short for Persistent, Bio-accumulative and Toxic).

ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO.18 5.1.2 Sediment organisms 5.1.3 Other aquatic organisms 5.2 Terrestrial compartment 5.3 Atmospheric compartment 5.4 Indirect exposure via the food chain 6 PBT AND VPVB 6.1 PBT, vPvB assessment Priority shall be given to registrations of substances which have or may have PBT, vPvB, sensitising and/or carcinogenic, mutagenic or toxic for reproduction (CMR) properties, or substances classified as dangerous according to Directive 67/548/EEC above 100 tonnes per year with uses resulting in widespread and diffuse exposure. There is a strong demand for early stage identification of potential Substances of Very High Concern (SVHC). SVHCs are substances that are classified as carcinogenic, mutagenic or reprotoxic (CMR); persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB); or as substances with an equivalent level of concern, like endocrine disruption (ED). The proposal shall include the identity of substance(s) concerned and whether it is proposed to be identified as a CMR according to Article 57(a), (b) or (c), a PBT according to Article 57(d), a vPvB according to Article 57(e), or a substance of equivalent concern according to Article 57(f). cmr / pbt KREATiS is a unique organisation offering you in silico ecotoxicology, mammalian toxicology and physical chemistry predictions to screen the hazards of your substance or to complete your regulatory dossiers or boost your R&D in the most time and cost efficient way possible using: As a result, once a PBT chemical is released into the environment it will accumulate and persist in fatty tissues of animals and end up in the food chain, concentrating on the top, affecting mainly predators such as fish, predatory birds and mammals (e.g. Polar bears, seals, whales), including humans. Overview and Comparison of PBT and vPvB Criteria in EU and USA. Little Pro on 2017-05-25 Views: .

CMR, PBT and vPvB > 1% weight ) should be listed in MSDS, only.
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Andra faror. · Resultat av PBT- och vPvB-bedömningen CMR-effekter (cancerframkallande, mutagena och reproduktionstoxiska egenskaper). · Mutagenitet i CMR-ämnen Cancerframkallande, mutagena och reproduktionsstörande ämnen. PBT- eller vPvB-ämne Långsamt sönderfallande, bioackumulerande och PBT/vPvB: Beståndsdelar är inte PBT/vPvB enligt kriterierna i REACH Orsaker inte hudsensibilisering (Vinsyra). OECD 429.

Cat. 2 CMR. 22. For those substances having a property of carcinogenicity, mutagenicity and reproductive toxicity.
Marginalised

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Substances of very high concern include substances with CMR (Carcinogenic, Mutagenic, reproductive toxic), PBT/vPvB and ED (Endocrine Disruptive) properties and substances of equivalent concern (see further in e.g. article 55-66 of REACH).

· Results of PBT and vPvB assessment. · PBT: Not applicable. CMR effects (carcinogenity, mutagenicity and toxicity for reproduction): None. 2008년 9월 6일 REACH용어중 CMR, PBT, vPvB 라는 용어가 있습니다.

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Jul 4, 2012 Table 2 Previous SVHC intentions addressing CMR impurities/minor coal- derived substances in Part 3. (d) PBT. (e) vPvB. 13/01/2010.

CMR-ämne; PBT; vPvB; ämnen med effekter som motsvarar ovanstående punkter och därför ger anledning till motsvarande oro, till exempel CMR, hormonstörande ämnen, PBT eller vPvB. • att artiklarna i vissa fall är svårtydliga.

summary fact sheet pbt working group – pbt list no. 56 tc nes subgroup on identification of pbt and vpvp substances results of the evaluation of the pbt/vpvb proposal for identification of a substance as a cmr, pbt, vpvb or a substance of an equivalent level of concern

For colorants, polymers, and preservatives, the toxicological endpoints in the Master cmr / pbt KREATiS is a unique organisation offering you in silico ecotoxicology, mammalian toxicology and physical chemistry predictions to screen the hazards of your substance or to complete your regulatory dossiers or boost your R&D in the most time and cost efficient way possible using: 36 For a substance that does not fall within the CMR, PBT or vPvB hazard categories specifically identified by the legislature as being of very high concern, its identification as such under Article 57(f) of the REACH Regulation, on account of a level of concern equivalent to those of CMR, PBT or vPvB substances, also involves ensuring that, amongst the different regimes established by that regulation, … POPs (Persistent Organic Pollutants) and Very Persitent and Very Bioaccumulative substances (vPvBs) and Persistent, Bioaccumulative and Toxic substances (PBTs) are generally considered to be substances of very high concern. Substances of very high concern include substances with CMR (Carcinogenic, Mutagenic, reproductive toxic), PBT/vPvB and ED Priority shall be given to registrations of substances which have or may have PBT, vPvB, sensitising and/or carcinogenic, mutagenic or toxic for reproduction (CMR) properties, or substances classified as dangerous according to Directive 67/548/EEC above 100 tonnes per year with uses resulting in widespread and diffuse exposure. 2021-02-01 Officially classified CMR (carcinogenic, mutagenic and reprotoxic) substances, by default fulfilling REACH SVHC criteria, and for which a non-intermediate use could be expected.

eCollection 2020. Management of PBT/vPvB substances under REACH. The REACH Regulation pays specific attention to the PBT/vPvB concern. One aim of the REACH Regulation is the substitution of PBT and vPvB substances where suitable technically and economically viable alternatives are available.